Paper

The metabolic roots of senescence: mechanisms and opportunities for intervention

Published Oct 1, 2021 · Christopher D. Wiley, J. Campisi

Nature Metabolism

375

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Abstract

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Literature ReviewRigorous JournalHighly Cited

Study Snapshot

Cellular senescence promotes metabolic diseases, which in turn promote cellular senescence, and effective interventions should break this feedback cycle to mitigate the pro-aging effects of cellular senescence.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

The metabolic roots of senescence: mechanisms and opportunities for intervention

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